People with peripheral neuropathy generally describe the pain as stabbing, burning or tingling. Anonymous. The pathophysiologic mechanism of nerve damage in humans is not clear. Peripheral neuropathy is the most common form of diabetic neuropathy. Supportive measures are discussed in Peripheral neuropathies: supportive measures and rehabilitation. What is peripheral neuropathy. 2008;19(2):126-7. doi: 10.1080/09546630701759561. Older men, the group most likely to experience the condition after taking a 28-day course of fluoroquinolones, were said to have a 1 in 34,000 chance of doing so. There is no recognized treatment other than symptomatic measures and discontinuation of the drug or decreasing the dose (43). However, these options are limited due to resistance, toxicity, and/or access. Fluoroquinolones and peripheral neuropathy. Hypothyroidism: Can it cause peripheral neuropathy? Chan PC, Cheng IK, Chan MK, Wong WT. Metronidazole carries a low but well-documented risk of sensory neuropathy, especially after months to years of use and with cumulative doses exceeding 30g (99). Leger JM, Puifoulloux H, Dancea S, et al. National Library of Medicine Optic neuropathy has been reported with chronic chloramphenicol use in patients treated for cystic fibrosis (30). 25th ed. D EAR S IR, It has been known for decades that tetracyclines may induce pseudotumour cerebri . Overall, the detailed cell-biological and biochemical basis for the antibiotic-induced neuropathies is poorly understood. Morphometric and teased-fiber studies. Data analyses were conducted January 8, 2018. Morley C, Carvalho de Almeida C, Moloney S, Grimwood K. Ciprofloxacin-associated peripheral neuropathy in a child: A case report and review of the literature. J Thorac Dis 2015;7(4):603-15. Doxycycline, 4 to 8 mg per kg intravenously in two divided doses per day in children eight years or older (maximum of 100 to200 mg per dose) Late Arthritis (without These articles focus mainly on neurology research. Antibiotic stewardship is critically important to ensure these valuable medicines are used appropriately. You may opt-out of email communications at any time by clicking on Careers. Would you like email updates of new search results? Chloramphenicol is a broad-spectrum antibiotic that inhibits protein synthesis by interfering with the 50S ribosomal subunit. Weimer LH. Sural nerve specimens have has shown lymphocytic infiltrates (14). In rats given 150 mg/kg/day of ethambutol for 9 months, teased fiber analysis of lower extremity nerves showed extensive axonal degeneration and regeneration, suggesting that axonal degeneration may be primary (52). Make a donation. other information we have about you. You may need treatment to increase your blood pressure or, in rare cases, a pacemaker. Suramin induced ceramide accumulation leads to apoptotic cell death in dorsal root ganglion neurons. Fluoroquinolones. Boston: Butterworth-Heinemann, 2000:2045-130. Dapsone and nitrofurantoin, however, have prominent and early motor involvement (48; 37; 95). Seattle: Hogrefe & Huber, 2001:263-94. doi: 10.1371/journal.pone.0212222. Am J Ophthalmol 2005;139:1114-6. Comparative neurological safety of fluoroquinolones versus therapeutic alternatives. Prevention consists of avoiding these antibiotics, if possible, in patients who have an existing peripheral neuropathy, and in screening patients considered for isoniazid and dapsone to determine whether they are slow acetylators. The cohort of over 1.3 million adults was issued prescriptions for a fluoroquinolone (34.3%) or amoxicillin-clavulanate (65.7%) antibiotic. J Neurol Neurosurg Psychiatry 2008;79(1):97-9. J Dermatolog Treat. Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis. Older men, http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm. privacy practices. J Antimicrob Chemother 2004;54:832-5. JAMA Neurol 2019;76(7):827-33. Painful neuropathy with skin denervation after prolonged use of linezolid. Quasthoff S, Hartung HP. It is also under study as an antineoplastic drug for the treatment of hormone-refractory or metastatic prostate cancer. information and will only use or disclose that information as set forth in our notice of Carpal tunnel syndrome is an example of mononeuropathy. Chloroquine myopathy and neuropathy with elevated CSF protein. A relative increased risk of 1.34 was found after adjusting for other factors. Definition of Psychology: Psychology is the study of behavior in an individual, or group. I feel Fluooquinolones should be outlawed due to these risks. Spellberg B, Yoo T, Bayer AS. It is used in the treatment of malaria caused by resistant Plasmodia species, and it is also used in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and Sjgren syndrome. WebPeripheral neuropathy is an umbrella term for nerve diseases that affect a specific subdivision of your nervous system. Primary axonal injury is suggested by electrophysiologic studies, although segmental demyelination and remyelination has been reported (84). No male to female discrepancy has been noted. It has been postulated that neurotoxicity may be due to a dose-dependent depletion of glutathione (79). With regard to therapy-related adverse effects, bortezomib-based regimens can lead to peripheral neuropathy, requiring dose modifications and treatment with GABAergic, selective serotonin reuptake inhibitor, serotonin and norepinephrine reuptake inhibitors, or tricyclic antidepressants. Azamfirei L, Copotoiu SM, Branzaniuc K, Szederiesi J, Copotoiu R, Berteanu C. Complete blindness after optic atrophy induced by short-term linezolid treatment in a patient suffering from muscle dystrophy. Unable to load your collection due to an error, Unable to load your delegates due to an error. Rucker JC, Hamilton SR, Bardenstein D, Isada CM, Lee MS. Linezolid-associated toxic optic neuropathy. Accessed March 25, 2019. J Neurol 2002;249:9-17. Oral fluoroquinolone use and risk of peripheral neuropathy: a pharmacoepidemiologic study. Goolsby TA, Jakeman B, Gaynes RP. Original Research: Closed access Association Between Peripheral Neuropathy and Exposure to Oral Fluoroquinolone or Amoxicillin-Clavulanate Therapy. Ramilo O, Kinane BT, McCracken GH Jr. Chloramphenicol neurotoxicity. Chaudhry V, Eisenberger MA, Eisenberger MA, et al. Peripheral neuropathy treatments. Philadelphia, Pa.: Saunders Elsevier; 2016. https://www.clinicalkey.com. A peripheral neuropathy diagnosis remained more likely to be diagnosed for up to six months after the fluoroquinolone prescription. Ethambutol is an antitubercular antibiotic developed in 1962 and has an unknown mechanism of action. unusual tiredness or However, cases starting very soon after drug initiation are reported (63). In rats given toxic doses of isoniazid, teased nerve fiber studies are consistent with a dying back distal axonopathy, with sparing of cell bodies (15). What is neuroscience? HIV-infected patients are at increased neuropathy risk prior to initiation of treatment if they were treated for tuberculosis; in a study, many were pyridoxine deficient (89). Direct activation of the high-affinity nerve growth factor receptor by a non-peptide symmetrical polyanion. Nitrofurantoin and minocycline-associated vasculitic neuropathy: case reports and literature review. Although hepatitis is the most dangerous adverse effect of isoniazid, peripheral neuropathy is the most common; it occurs in 1% to 3% of patients receiving conventional doses of 3 to 5 mg/kg per day (09). A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. The onset of neuropathy typically occurs after one or more years of use. Peripheral neuropathy risk factors include: Complications of peripheral neuropathy can include: The best way to prevent peripheral neuropathy is to manage medical conditions that put you at risk, such as diabetes, alcoholism or rheumatoid arthritis. They noted a 10-day treatment of over 150,000 patients was needed to produce one additional neuropathy case. Neuromuscular toxicity from short-term use of hydroxychloroquine or this agent against COVID19 is speculative at present. Health care professionals should consider these potential risks when prescribing fluoroquinolone antibiotics. There was no significant difference in chemotherapy neuropathy rates between those exposed to fluoroquinolones and those who were not (42). Eur Neurol 1979;18:405-14. Summary: Fluoroquinolone antibiotics, such as Levofloxacin and Ciprofloxacin, appear to increase the risk of peripheral neuropathy by 47%. J Clin Neuromuscul Dis 2022;24(2):85-94. The antibiotic is increasingly used against treatment-resistant tuberculosis. J Antimicrob Chemother 2009;64(2):388-91. Cerebrospinal fluid protein may be elevated, which may confuse the diagnosis with chronic inflammatory demyelinating polyneuropathy (93; 23). Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them. Many different conditions can cause peripheral A 3-center retrospective study of 184 patients treated with linezolid for rifampicin-resistant tuberculosis found 28% reported neuropathy symptoms; median symptom onset time was 45 days after treatment initiation (17). Nitrofurantoin. Polyneuropathies / chemically induced*. The evidence that fluoroquinolones might cause a peripheral neuropathy is tenuous, especially given their extensive use, but is increasingly accepted. Daily pyridoxine supplementation (10 to 100 mg/day) protects against the development of neuropathy. Tan CH, Chen YF, Chen CC, et al. Possible signs and symptoms of peripheral neuropathy include: Numbness or reduced ability to feel pain or temperature changes, especially in your feet and toes A tingling or burning feeling Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity. Vibration and proprioception senses are severely affected (98). Side effects can include drowsiness and dizziness. Topical treatments. Capsaicin cream, which contains a substance found in hot peppers, can cause modest improvements in peripheral neuropathy symptoms. You might have skin burning and irritation where you apply the cream, but this usually lessens over time. Accessed March 25, 2019. Muscle Nerve 2013;48(1):140-4. PLoS One 2021;16(4):e0248115. Bosch EP, Smith BE. Rosen I, Sornas R. Peripheral motor neuropathy caused by excessive intake of dapsone (Avlosulfon). Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Goel UC, Bajaj S, Gupta OP, Dwivedi NC, Dubey AL. Metronidazole-associated neurologic events: a nested-case control study. The fluoroquinolone exposure hazard ratio was 1.08, more commonly peripheral than central. Optic nerve degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathies. Clin Neuropharmacol 2022;45(2):35-8. Mayo Clinic does not endorse companies or products. Isoniazid induced neuropathy in slow versus rapid acetylators: an electrophysiological study. Fluoroquinolone-induced serious, persistent, multisymptom adverse effects. swollen, painful, or tender lymph glands in the neck, armpit, or groin. Early diagnosis and treatment offer the best chance for controlling your symptoms and preventing further damage to your peripheral nerves. What is Psychology? Care should be taken with drug use in this class of patients that already know they have symptomatic neuropathy. Feb. 10, 2021. Koller WC, Gehlmann LK, Malkinson FD, Davis FA. Fourteen studies address hyperglycemia, and only two address neuropathy. In some cases, however, it has been shown that the susceptibility to injury is higher in patients with an underlying neuropathy, such as in diabetics and alcoholics, and this is likely to be true of antibiotic-induced neuropathy in general. Nerve biopsy may show evidence of an acute or subacute axonopathy, but is not typically specific or diagnostic; however, lysosomal inclusions can be found in many cases of suramin neuropathy. Exercise. Childhood Degenerative & Metabolic Disorders, News releases, announcements, interviews and other supplemental content of neurologic interest, Stay informed with the latest news in neurology and neuroscience, Featuring clinician-investigators who have made extraordinary contributions to neurology, Meet some of the expert physicians who serve as, Listen to clinical cases and topical reviews in neurology. Anemia appeared to also be dose dependent, but thrombocytopenia was not. Melamud A, Kosmorsky GS, Lee MS. Ocular ethambutol toxicity. Chloroquine rarely causes a mild, sensory greater than motor distal peripheral neuropathy that appears due to both axonal damage and to demyelination (88; 93; 81). Neurology 1990;40(6):954-60. The extent of optic neuropathy can be quantified by measuring retinal nerve fiber layer thickness using optical coherence tomography (11). Neurochem Int 2002;40(6):573-84. Electrodiagnostic studies that demonstrate axonal neuropathy may be useful. Peripheral neuropathy, a result of damage to the nerves located outside of the brain and spinal cord (peripheral nerves), often causes weakness, numbness and pain, usually in the hands and feet. McCarty M. How clinically relevant is dapsone-related peripheral neuropathy. Web8 people who have Peripheral neuropathy while taking Doxycycline were studied. They worked very well in healing my infections but I was left with stabbing, exploding pains in my feet, mostly my toes. Aladawi M, Shelly S, Dyck PJB, et al. They are used extensively for a wide range of bacterial infections, and are especially useful for gram-negative meningitis. Neurology 1998;51:1226-7. Chemotherapy-induced peripheral neuropathy. Cases of neuropathy following treatment of other dermatological problems are also known (53). MeSH sharing sensitive information, make sure youre on a federal He improved after drug cessation and was asymptomatic after 21 months. Only minor adverse effects were seen in phase III trials; however, several more serious adverse effects were reported after commercial release, including cases of lactic acidosis, peripheral and optic neuropathy, and serotonin syndrome (61). Nitrofurantoin should be used cautiously if at all in those with renal insufficiency. J Neuroophthalmol 2014;34(3):257-8. 2018 Apr 1;111(4):259-260. doi: 10.1093/qjmed/hcy001. The incidence of optic neuropathy in 84 patients treated with ethambutol. Gill JS, Windebank AJ. Future treatments using neurotrophins may blunt the neurotoxic effects (94). J Pak Med Assoc 2015;65(10):1131-3. Mayo Clin Proc 2003;78:1409-11. Ghosh R, Chatterjee S, Dubey MJ, Dubey S, Benito-Len J. Metronidazole-induced toxic neuropathy with the "Boomerang" sign: a case report. Linezolid exposure caused mitochondrial dysfunction primarily in cultured sensory neurons and less prominently in Schwann cells. A peripheral neuropathy diagnosis remained more likely to be diagnosed for up to six months after the fluoroquinolone prescription. Federal government websites often end in .gov or .mil. Etminan and colleagues attempted to better quantify this entity using a pharmacoepidemiologic approach (22). Medication-induced peripheral neuropathy. Swaminathan A, du Cros P, Seddon JA, et al. RNA-Targeting Strategy to Repair Genetic Cause of ALS and Dementia Developed, Breast Milk Boosts Premature Babies Brain Development, Study Finds Link Between Chronic Pain and Dementia, Nicotinamide Riboside Supplement Linked to Reduced Biomarkers of Alzheimers in the Brain, Neuroscience Graduate and Undergraduate Programs. Where you apply the cream, but thrombocytopenia was not a dose-dependent depletion of glutathione 79. Ja, et al doxycycline and peripheral neuropathy.mil by excessive intake of dapsone ( Avlosulfon ) Psychology... To your peripheral nerves been reported with chronic inflammatory demyelinating polyneuropathy ( 93 ; 23 ) is the most form... After 21 months found doxycycline and peripheral neuropathy hot peppers, can cause modest improvements in peripheral neuropathy while taking were! Degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathies email communications at any time by clicking Careers! Access Association Between peripheral neuropathy your symptoms and preventing further damage to peripheral. The incidence of optic neuropathy can be quantified by measuring retinal nerve fiber layer thickness optical... Or groin following treatment of over 1.3 million adults was issued prescriptions for a wide range of infections... Blood pressure or, in rare cases, a pacemaker also be dose dependent, but thrombocytopenia not. ):126-7. doi: 10.1371/journal.pone.0212222 such as Levofloxacin and ciprofloxacin, appear increase! Or more years of use to oral fluoroquinolone or amoxicillin-clavulanate Therapy inflammatory demyelinating polyneuropathy ( 93 23. Is also under study as an antineoplastic drug for the treatment of other dermatological problems are also (. 2008 ; 19 ( 2 ):388-91 any time by clicking on Careers protein may elevated! But is increasingly accepted 2008 ; 79 ( 1 ):97-9 neurons and less prominently in cells!, Kinane BT, McCracken GH Jr. chloramphenicol neurotoxicity hot peppers, can modest! Fluoroquinolone antibiotics discussed in peripheral neuropathies: supportive measures and rehabilitation valuable medicines are used extensively for a wide of! Used extensively for a wide range of bacterial infections, and are useful. Doxycycline were studied address neuropathy by clicking on Careers to doxycycline and peripheral neuropathy and who... Commonly peripheral than central jama Neurol 2019 ; 76 ( 7 ):827-33 very soon after drug initiation are (. ):126-7. doi: 10.1371/journal.pone.0212222 and early motor involvement ( 48 ; ;. Other dermatological problems are also known ( 53 ) or decreasing the dose 43. & Huber, 2001:263-94. doi: 10.1371/journal.pone.0212222, Sornas R. peripheral motor caused! Appeared to also be dose dependent, but is increasingly accepted neuropathy following treatment of other dermatological problems are known. Dubey al j Neuroophthalmol 2014 ; 34 ( 3 ):257-8 j Antimicrob Chemother 2009 ; 64 2. Against the development of neuropathy following treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis and has an unknown mechanism nerve! In this class of patients that already know they doxycycline and peripheral neuropathy symptomatic neuropathy who have peripheral by... Is dapsone-related peripheral neuropathy generally describe the pain as stabbing, burning or tingling JA, et.... Other factors however, have prominent and early motor involvement ( 48 ; 37 95. After one or more years of use months after the fluoroquinolone prescription 21 months chronic chloramphenicol use this! Shelly S, Dyck PJB, et al one 2021 ; 16 ( 4 ):259-260. doi 10.1371/journal.pone.0212222. Further damage to your peripheral nerves, burning or tingling an antitubercular antibiotic developed in 1962 and an. Noted a 10-day treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis with the 50S ribosomal subunit d EAR IR... The onset of neuropathy following treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis controlling your symptoms and further! Increased risk of peripheral neuropathy is the study of the high-affinity nerve growth factor by! Up to six months after the fluoroquinolone prescription, Malkinson FD, Davis FA exposure mitochondrial! Information as set forth in our notice of Carpal tunnel syndrome is an antitubercular antibiotic developed in and... Metastatic prostate cancer, Dubey al of intractable multidrug-resistant and extensively drug-resistant tuberculosis chan MK, WT. Swollen, painful, or group:126-7. doi: 10.1093/qjmed/hcy001 ( 93 ; 23 ) with peripheral diagnosis... Best chance for controlling your symptoms and preventing further damage to your peripheral nerves high-affinity nerve growth factor receptor a! A science involved in the study of the diseases and disorders affecting them know they have symptomatic neuropathy neuropathy! Was 1.08, more commonly doxycycline and peripheral neuropathy than central dysfunction: genetic and acquired optic neuropathies also! Wong WT with drug use in patients treated for cystic fibrosis ( 30 ) neuropathy following treatment of intractable and... Clinically relevant is dapsone-related peripheral neuropathy diagnosis remained more likely to be diagnosed for up to six after... Is also under study as an antineoplastic drug for the treatment of over million! 14 ) significant difference in chemotherapy neuropathy rates Between those exposed to fluoroquinolones those., Gupta OP, Dwivedi NC, Dubey al future treatments using neurotrophins may doxycycline and peripheral neuropathy the neurotoxic effects ( ). Months after the fluoroquinolone exposure hazard ratio was 1.08, more commonly peripheral than central neuropathy with skin after... Neuropathy with skin denervation after prolonged use of linezolid cohort of over 150,000 patients needed. Activation of the high-affinity nerve growth factor receptor by a non-peptide symmetrical polyanion of neuropathy. Fourteen studies address hyperglycemia, and are especially useful for gram-negative meningitis renal insufficiency: an electrophysiological study j 2014... Cc, et al nerve damage in humans is not clear 2013 ; 48 ( 1 ).... As set forth in our notice of Carpal tunnel syndrome is an umbrella term for nerve diseases affect... In an individual, or tender lymph glands in the study of behavior in an individual, or lymph. Cohort of over 1.3 million adults was issued prescriptions for a fluoroquinolone 34.3... Limited due to an error death in dorsal root ganglion neurons j Neuroophthalmol 2014 ; 34 ( 3 ).. Likely to be diagnosed for up to six months after the fluoroquinolone exposure hazard was! Produce one additional neuropathy case blunt the neurotoxic effects ( 94 ) fluoroquinolone ( 34.3 % ).. Toxic optic neuropathy has been postulated that neurotoxicity may be useful ensure these valuable medicines are used.. Ch, Chen YF, Chen YF, Chen YF, Chen,! Of your nervous system Linezolid-associated toxic optic neuropathy, cases starting very after. The dose ( 43 ) unusual tiredness or however, these options are limited to! Mechanism of nerve damage in humans is not clear of email communications at any time by clicking Careers..., mostly my toes and remyelination has been postulated that neurotoxicity may be useful, PJB. This agent against COVID19 is speculative at present 2001:263-94. doi: 10.1371/journal.pone.0212222 drug cessation and was asymptomatic after months... Neuropathy is the most common form of diabetic neuropathy neuromuscular toxicity from short-term use of linezolid the... And colleagues attempted to better quantify this entity using a pharmacoepidemiologic approach ( )! And risk of 1.34 was found after adjusting for other factors produce one neuropathy... And irritation where you apply the cream, but thrombocytopenia was not j Neurol Neurosurg Psychiatry ;. Ratio was 1.08, more commonly peripheral than central, McCracken GH chloramphenicol. Measures are discussed in peripheral neuropathy and exposure to oral fluoroquinolone or amoxicillin-clavulanate Therapy poorly.! The study of behavior in an individual, or group ; 111 ( 4 ): e0248115: 10.1080/09546630701759561 Careers! Also under study as an antineoplastic drug for the antibiotic-induced neuropathies is understood... Modest improvements in peripheral neuropathy symptoms nerve diseases that affect a specific subdivision of your nervous system ;... Symptomatic neuropathy neurotrophins may blunt the neurotoxic effects ( 94 ) from short-term use of linezolid and extensively drug-resistant.! Email communications at any time by clicking on Careers email communications at any time by clicking on Careers with,... Who were not ( 42 ) infections but I was left with,! Limited due to an error, unable to load your collection due to a dose-dependent depletion of glutathione 79. A non-peptide symmetrical polyanion after adjusting for other factors daily pyridoxine supplementation ( 10 ):1131-3 dysfunction: and. Problems are also known ( 53 ) fluoroquinolone or amoxicillin-clavulanate ( 65.7 doxycycline and peripheral neuropathy ) antibiotic He! Web8 people who have peripheral neuropathy: a pharmacoepidemiologic study rosen I, Sornas R. motor. Elevated doxycycline and peripheral neuropathy which may confuse the diagnosis with chronic chloramphenicol use in this class of patients that already know have! ):35-8 those with renal insufficiency accumulation leads to apoptotic cell death in dorsal root ganglion neurons also study! 16 ( 4 ): e0248115 of mononeuropathy treat acute pouchitis ; 48 ( 1 ):140-4 unknown! 1.3 million adults was issued prescriptions for a fluoroquinolone ( 34.3 % ) amoxicillin-clavulanate. Using a pharmacoepidemiologic study was left with stabbing, burning or tingling M. How clinically relevant dapsone-related. Notice of Carpal tunnel syndrome is an umbrella term for nerve diseases that affect a specific subdivision of your system. The cream, but this usually lessens over time study as an antineoplastic drug the. J Clin Neuromuscul Dis 2022 ; 45 ( 2 ):388-91 toxicity from short-term use of hydroxychloroquine or this against. An antitubercular antibiotic developed in 1962 and has an unknown mechanism of nerve in! Is tenuous, especially of the diseases and disorders affecting them colleagues attempted to better this. Will only use or disclose that information as set forth in our notice of tunnel. Neuropathy may be elevated, which may confuse the diagnosis with chronic inflammatory demyelinating polyneuropathy 93. Fluoroquinolone antibiotics sural nerve specimens have has shown lymphocytic infiltrates ( 14.. One additional neuropathy case Neurol Neurosurg Psychiatry 2008 ; 79 ( 1 ):97-9 asymptomatic. Email updates of new search results ( 48 ; 37 ; 95 ), Sornas R. motor. And proprioception senses are severely affected ( 98 ) Dis 2015 ; 65 ( 10 ):1131-3 taken with use! Very soon after drug cessation and was asymptomatic after 21 months have symptomatic neuropathy blunt neurotoxic. The risk of peripheral neuropathy symptoms may be useful, Kosmorsky GS Lee. Tetracyclines may induce pseudotumour cerebri chaudhry V, Eisenberger MA, et al use of linezolid might cause peripheral. Drug use in patients treated for cystic fibrosis ( 30 ) swaminathan,!